Revealing of Antiinflamatory Agent from Zingiber officinale var. Roscoe via IKK-B Inhibitor Mechanism through In Silico Simulation
نویسندگان
چکیده
Inflammation is a response to the immune system from attack by infectious agents. Its condition triggered phase of dilatation in blood flow and increased membrane permeability area infection. The results vitro research showed that compounds Zingiber officinale var. Roscoe extract could trigger decrease NF-κB protein activity pro-inflammatory cytokine production. influenced IKK-B enzyme for phosphorylation IκBα complexes, triggers dissociation releases proinflammatory gene expression. Extract rhizome can prevent treat inflammation human body, this treatment classified as an alternative according previous research. This study aims identify anti-inflammatory potential var through mechanism inhibition IKKB bioinformatics simulation. predicted act agent 6-shogaol with at Ser177 Ser181 residues, drug-like molecule, must undergo further analysis provide strong scientific evidence.
منابع مشابه
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ژورنال
عنوان ژورنال: Sainstek: Jurnal Ilmiah Ilmu Pengetahuan dan Teknologi
سال: 2022
ISSN: ['1410-8070', '2460-1039']
DOI: https://doi.org/10.24036/sainstek/vol1-iss01/4